ErgoElite™
L-(+)-Ergothioneine EGT Cosmetic 99.9%
Chinese Supplier Factory Manufacturer
Antioxidant Champion, The King Returns!!
What is ErgoElite™ L-(+)-Ergothioneine (EGT) Cosmetic Grade?
L-(+)-Ergothioneine (EGT) is a powerful, naturally occurring antioxidant amino acid, famed for neutralizing free radicals, shielding cells from oxidative harm, and bolstering mitochondrial health. Its unparalleled antioxidant capacity and over 99.9% purity make EGT a coveted ingredient in skincare and supplements, enhancing skin vitality and overall health.
ETProtein, a leading innovator and supplier, has significantly reduced EGT’s cost, broadening its accessibility in cosmetic industries. We are dedicated to delivering the king of antioxidants through our brand ErgoElite™ worldwide, ensuring everyone can experience its beauty benefits. Please contact us for more information today!
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What is L-(+)-Ergothioneine EGT?
ErgoElite™
Purity>99.9% Cosmetic Grade
What is L-(+)-Ergothioneine EGT?
L-Ergothioneine is a standout amino acid found in mushrooms and various foods, emerging as a skincare powerhouse. This potent antioxidant combats oxidative stress and free radical damage, offering promising benefits for skin health. It’s especially noted for its anti-aging effects, reducing inflammation and supporting skin’s overall health. As the beauty industry evolves, cosmetic brands and formulators are increasingly incorporating L-Ergothioneine into products for its deep skin penetration and cellular protection. This ingredient not only helps preserve collagen and elastin, crucial for youthful skin, but also aligns with the growing demand for natural, effective skincare solutions. L-Ergothioneine represents a significant advancement in anti-aging and skin care, promising a future where cosmetics provide genuine, noticeable benefits.
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What is the Science behind
ErgoElite™ L-(+)-Ergothioneine EGT?
What distinguishes ErgoElite™ L-(+)-Ergothioneine from other antioxidants in combating cellular aging?
Antioxidants Capable of Mitochondrial Penetration <br>Activation of Endogenous Antioxidant Systems
Ergothioneine stands out among natural antioxidants for its unique ability to penetrate both the mitochondria and the cell nucleus, a capability attributed to its well-defined mechanism of action. This distinctiveness is primarily due to the presence of the specific transport protein OCTN1 on keratinocytes and fibroblasts within the skin, allowing Ergothioneine to traverse cell membranes and enter cell mitochondria directly. Upon entry, it effectively neutralizes reactive oxygen free radicals, thus playing a pivotal role in mitigating oxidative stress.
From the perspective of cellular aging, the process is largely driven by the accumulation of oxidative substances produced within the mitochondria. These substances gradually damage the cell membrane, leading to cell apoptosis. Addressing oxidative damage at the mitochondrial level is therefore crucial in combating aging. Ergothioneine, through its targeted interaction with OCTN1, not only purges these harmful free radicals but also activates other antioxidant enzymes, such as glutathione peroxidase and superoxide dismutase. These enzymes are instrumental in scavenging reactive oxygen species (ROS), thereby synergistically amplifying the antioxidant defense mechanism within cells.
Moreover, Ergothioneine’s ability to initiate a cooperative response among various antioxidant components exemplifies its exceptional efficacy. It not only acts directly against oxidative threats but also empowers the cell’s endogenous antioxidant system, thereby embodying a leadership quality in the realm of antioxidant defense. This multifaceted approach positions Ergothioneine as a potent force against cellular aging, offering a comprehensive strategy to enhance the cell’s inherent antioxidative capacity.
Ergothioneine, binding specifically with OCTN-1, penetrates mitochondria to efficiently neutralize free radicals and activate other antioxidants.
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Ergothioneine transporter OCTN1
Expression of ergothioneine transporter OCTN1 on stratum corneum cells (green)
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What is the Unique Benefits of ErgoElite™ L-(+)-Ergothioneine EGT for Skincare?
King of AntiOxidant, Anti aging
.
Sun Protection, UV Protection
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Brighten and Whiten Skin
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Reduces cellular inflammation
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L-Ergothioneine VS. Other Antioxidants
>6*Glutathione, >6*Astaxanthin
>46*Coenzyme Q10, >3017*Vitamin E
L-Ergothioneine: Transforming Anti-Aging Skincare with Superior Antioxidant Power
In the dynamic and competitive landscape of the beauty industry, the demand for effective anti-aging solutions is incessant. L-Ergothioneine distinguishes itself as a powerful antioxidant amino acid, rapidly becoming indispensable in skincare formulations. This compound sets itself apart from other antioxidants by its absence in human biosynthesis, underscoring the necessity of its external application for maintaining skin health. It effectively combats oxidative stress, mitigates visible aging signs such as wrinkles and fine lines, and fosters a rejuvenated skin appearance through enhanced collagen synthesis and UV defense mechanisms.
The integration of L-Ergothioneine into skincare products enables brands to offer significant anti-aging advantages, pioneering advancements in skincare treatments that provide tangible benefits. Notably, L-Ergothioneine’s antioxidant capability far surpasses that of other well-known antioxidants; DPPH assay results reveal its free radical scavenging capacity is sixfold greater than that of glutathione and astaxanthin, impressive forty-sixfold higher than coenzyme Q10, and impressive 3.017 greater than Vitamin E. This remarkable efficacy solidifies L-Ergothioneine’s role as a revolutionary ingredient in anti-aging skincare, promising a future where skincare solutions not only promise but deliver profound anti-aging results.
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The DPPH test results show that at the same concentration, L-Ergothioneine's ability to scavenge free radicals >6 times of Glutathione >6 times of Astaxanthin > 46 times of Coenzyme Q10
The DPPH test results show L-Ergothioneine's ability to scavenge free radicals >3017 times of Vitamin E
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EGT metabolism in the cell against UV and Sun
EGT significantly reduces the ROS induced by UV radiation
Sun Protection, UV Protection
Neutralizes UV-induced free radicals
protecting skin cells and DNA.
L-Ergothioneine: Transformative Antioxidant for UV Protection and Skin Health
L-Ergothioneine, offers significant UV protection, addressing one of the primary causes of skin damage including premature aging and potential skin cancer. Its ability to neutralize UV-induced free radicals protects skin cells and DNA from damage. Moreover, L-Ergothioneine’s anti-inflammatory properties provide soothing relief for sun-exposed skin, reducing redness and inflammation. It enhances the skin’s natural defenses and barrier function, leading to improved skin health, reduced fine lines, and better skin texture.
EGT, plays a crucial role in guarding cells against damage and inflammation triggered by external factors like UV light and reactive oxygen species (ROS). In response to cell stress or damage, the body increases production of OCTN-1 transporters to move EGT across cell membranes. Once inside, EGT employs various strategies to protect cells’ subcellular organelles. It quickly binds with metal ions in the cytoplasm, preventing them from causing additional damage through the Fenton reaction. EGT also helps regulate key enzymes, impacting the movement and levels of NAD+ in both the cytoplasm and mitochondria, which in turn, influences mitochondrial ROS levels. In the nucleus, it safeguards DNA transcription and defends against damage, particularly from copper ions. Furthermore, EGT reduces the production of inflammatory substances like TNF-α and interleukins, offering further cellular protection.
For cosmetic brands, incorporating L-Ergothioneine into skincare products promises not only effective UV protection but also anti-aging and skin-repairing benefits, positioning it as a transformative ingredient in sun protection and skincare formulations.
Superior Brighten and Whiten Skin Ability Supassing VC, Niacinamide, Decrease Melanocytes Hugely
L-ergothioneine (L-EGT) effectively inhibits tyrosinase activity by 87.62% at 1000 ppm, surpassing Vitamin C and Niacinamide, and thus enhances skin brightness and whitening.
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L-Ergothioneine: Whitens Skin 2-5 Times More Effectively Than Vitamin C, Significantly Outperforms Niacinamide
Many skincare and cosmetic products marketed as “instant whitening” merely contain titanium dioxide, an inorganic compound that provides physical coverage rather than addressing the root causes of skin discoloration.
The essence of skin brightening and whitening lies in inhibiting the production of melanin in the skin and preventing the transfer of existing melanin to the deeper layers of the epidermis. Melanin is synthesized by melanocytes in the skin, which possess a special enzyme called tyrosinase. This enzyme converts tyrosine into dopaquinone, which through several steps, becomes melanin. Once formed, melanin is transferred from melanocytes to the surrounding epidermal cells, causing changes in the skin’s natural color. Therefore, tyrosinase is critical in controlling the activity of melanocytes and dictates the rate of melanin synthesis. Increased tyrosinase activity leads to more melanin production; conversely, when tyrosinase activity is inhibited, the ability of melanocytes to produce melanin is reduced.
Data shows that compared to Vitamin C and niacinamide, ergothioneine at 1000 ppm can inhibit 87.62% of tyrosinase activity, which is significantly higher than the former compounds. This suggests that ergothioneine is more effective in enhancing skin brightness and whitening effects.
Reduces cellular inflammation
100% Safety, Sensitive skin
Longevity vitamins. Non-Irritating Ingredient
EGT is completely safe and extends cellular lifespan
L-Ergothioneine is a safe, naturally occurring antioxidant that is non-irritating and particularly beneficial for sensitive skin, recognized for its inclusion in the “longevity vitamins” essential for long-term health.
L-Ergothioneine is a highly safe ingredient, completely non-irritating, non-allergenic, and gentle enough for use during pregnancy, breastfeeding, or for skin needing repair after medical aesthetic procedures. Crucially, it is a naturally occurring compound in the human body, readily accepted by the skin without the need for a tolerance build-up. It is also odorless and tasteless, making it particularly suitable for sensitive skin types.
Unlike other antioxidants that may require a tolerance build-up, are unstable, can stain, or are less effective, ergothioneine stands out as highly versatile and effective.
In scientific studies, ergothioneine has been tested at doses up to 941 times the recommended daily intake (1600 mg/kg body weight per day) for 90 consecutive days without any harmful effects or toxic side effects observed. Research shows that ergothioneine can even extend cellular lifespan. Due to these outstanding properties, Dr. Bruce Ames included ergothioneine in his 2018 theory of “longevity vitamins.” He grouped it with well-known antioxidants and nutrients such as vitamin D, DHA, EHA, magnesium, carotenoids, and lutein, identifying these 41 compounds as essential for long-term health.
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Adopted by Luxury Cosmetic Brands
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EGT Is So Excellent!
Why Isn't It More Commonly Used?
Too Expensive!
What We Do?
We Cut The Price To Be Less Than 10%!
How we make it happen?
Our R&D team has lowered ergotamine production costs using biosynthesis, optimizing raw materials and fermentation processes to increase yield and ensure safety.
Our skilled R&D team has greatly reduced ergotamine production costs using biosynthesis, thanks to:
Enhanced Fermentation: boost ergotamine yield and production efficiency.
Optimized Metabolic Pathways: By modifying microbial pathways, we increase synthetic efficiency.
Faster Production, Higher Yield: Our methods cut fermentation time to 3-9 days and achieve up to 10 g/L, lowering cost per unit.
Safety: Using edible, non-GMO fungi ensures product safety, crucial for pharmaceuticals and aligned with safety standards.
Overall, these strategies enhance ergotamine yield and reduce costs, giving us a competitive edge.
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Walk Through Advanced Laboratory
Advanced equipment, High-tech methodologies, Highly educated researchers, Trustworthy partner
Our biosynthesis laboratory is outfitted with cutting-edge equipment and utilizes high-tech methodologies, ensuring that our research is conducted at the forefront of scientific innovation. Our team comprises highly educated individuals, all holding at least a master’s degree and doctor’s degree, which underpins our commitment to excellence and reliability in our field. This combination of advanced technology and skilled personnel makes our lab a trustworthy partner in biosynthesis research.
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Available Inventory and Fast Delivery Advanced equipment, Ample production capacity, Stock and Quick delivery
Our Facility is equipped with advanced equipment, and we have ample production capacity. We have stock available for orders under 10 kg, and we can deliver orders of 100KG within a 2-week timeframe.
Application Of Ergothioneine:
A Technical ResearchGuide
E BOOK written by ET Protein R&D Team
Experience the complete journey of L-Ergothioneine with our comprehensive e-book, passionately crafted by the experts at ETprotein. Dive into the science, innovation, and dedication behind our breakthrough product. We’re thrilled to share this wealth of knowledge with you for free! Get your copy today and join us in revolutionizing health and wellness.
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1.Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin,by Hui-Min Liu,Wei Tang ,Xiao-Yi Wang, Jing-Jing Jiang,Wei Zhang andWei Wang
2.The Antiaging Activity of Ergothioneine in UVA-lrradiatedHuman Dermal Fibroblasts via the Inhibition of the AP-1 Pathway and the Activation of Nrf2-Mediated Antioxidant Genes. By You-Cheng Hseu,Yugandhar Vudhya Gowrisankar, Xuan-Zao Chen,Yi-Chen Yang, and Hsin-Ling Yang
3.Comparison of Single and Combined Use of Ergothioneine, Ferulic Acid, and Glutathione as Antioxidants for the Prevention of Ultraviolet B Radiation-Induced Photoaging Damage in Human Skin Fibroblasts By Gregory J. Tsay, Shin-Yi Lin, Chien-Yu Li, Jeng-Leun Mau and Shu-Yao Tsai
4.The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages. By Sumito Yoshida1, Hiroaki Shime, Kenji Funami, Hiromi Takaki, Misako Matsumoto, Masanori Kasahara, Tsukasa Seya.