Keywords

Protein Tyrosine Phosphatase Interacting Protein 51, Mapk Pathway, Apoptosis, Tumor, Mitochondria-Associated Endoplasmic Reticulum Membranes

Abstract

Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is an evolutionarily conserved new mitochondrial protein that is widely expressed in mammals. It binds to a variety of proteins and participates in the transmission of cell signaling pathways. It is required for the normal progression of various life activities. Basically, the occurrence of various diseases is related to the abnormal expression of PTPIP51. This article reviews the research on the biological properties of PTPIP51, its role in the cell cycle, its relationship with apoptosis and autophagy, tumors and neurodegenerative diseases, and its role in memory. Protein tyrosine phosphatase interacting protein 51 (PTPIP51) is an evolutionarily conserved new type of mitochondrial protein widely expressed in mammals. Binding to multiple proteins to participate in the transmission of cellular signaling pathways is the basis for the normal conduct of various life activities. The occurrence of multiple diseases is all related to the abnormal expression of PTPIP51. This focuses review on the biological characteristics of PTPIP51, its role in the cell cycle, its association with apoptosis and autophagy, with tumor and neurodegenerative diseases, and in memory.

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Original research done by Yu Qun, Wang Haipeng, Zhang Wenbo, Chen Huailong, Shi Fei

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