Keywords

Recombinant Human Glucagon-Like Peptide, Teratogenic Sensitivity Phase Toxicity, Teratogenic Toxicity

Abstract

Background and purpose: To observe the embryotoxicity and teratogenic toxicity of recombinant human glucagon_likepeptide (rhglp) in rats through continuous administration during the embryonic organ formation period. Materials and methods: SD rats were used in the experiment, with >16 pregnant rats in each group. The test is divided into 3 dose groups (260, 130 and 65 ¦Ìg/kg), 1 positive control group and 1 solvent control group. The drug was administered continuously for 10 days during the embryonic organ formation period of rats (the 6th to 15th day of conception). The test drug and the negative control of normal saline at 1.0ml/kg were injected subcutaneously on the back of the neck every day. The positive control was acetylsalicylic acid (aspirin, asp). ) was administered daily at 10.0ml/kg. On the 20th day of pregnancy, the pregnant rats were sacrificed by cervical dislocation. Count the number of corpus luteum, number of implanted embryos, number of live fetuses, number of early stillbirths (including resorption fetuses) and number of late stillbirths. After observing the gender, appearance and weighing of the fetuses, 1/2 of the live fetuses from each litter were fixed in ethanol, softened with 2% potassium hydroxide, stained with alizarin red, and made transparent with glycerin to examine the bone development on a large-field instrument. The other 1/2 of the live fetuses were fixed with bouins solution, and the development of internal organs was examined on a large-field instrument. Results: No obvious fetal growth and development disorders or skeletal and visceral malformations were found in any dosage group of the tested drug. Conclusion: At a dose of <260 ¦Ìg/kg, recombinant human glucagon-like peptide has no embryotoxicity or teratogenic toxicity in rats.   For further details regarding this article and its research, please do not hesitate to contact our team for assistance. Original research done by Yu Yan, Lin Fei, Zhang Ruijuan, Zhang Zhenjun, Li Jingjing  

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