Keywords

Spleen Polypeptide Injection, Gastric Cancer, Spleen, Immune Killer Cell Activity

Abstract

Objective To explore the mechanism by which spleen polypeptide injection increases the activity of spleen immune killer cells in rats with gastric cancer. Methods 75 rats were taken, 60 of which were induced with N-methyl-N-nitro-nitrosoguanidine (MNNG) to establish a rat gastric cancer model. The random number table method was used to divide them into model group and low and medium group. , high-dose group; the remaining 15 healthy rats were given normal drinking water as the control group. Starting from the 36th week, the low, medium and high dose groups were injected with 0.06, 0.18 and 0.54 mL¡¤kg-1 spleen polypeptide injection into the tail vein respectively, while the control group and model group were injected with normal saline into the tail vein once a day for 35 days. . After the rats were sacrificed, the gastric histopathological changes were observed; the spleen index and spleen NK cell killing activity of each group were compared; the proportion of NK cells in the gastric tissue and spleen of each group and the expression of their surface-activated receptor (NKG2D), and the expression of NK cells in the gastric tissue were compared. Relative expression of NKG2D ligand histocompatibility complex class I associated gene A (MICA) mRNA and protein. Results In the model group, there were a large number of inflammatory cells infiltrating the lamina propria of the gastric mucosa, many cancerous cells, and the arrangement of mucosal glands was seriously disordered; in the low, medium, and high-dose groups, the inflammatory cells in the lamina propria of the gastric mucosa were reduced, the arrangement of mucosal glands was disordered, and the cancer cells The number decreased, with the mid-dose group showing the most significant reduction; spleen index, spleen NK cell killing activity, proportion of NK cells in spleen and gastric tissue, NKG2D expression, and relative expression of MICA mRNA and protein among groups, the control group had the highest, and the mid-dose group had the highest The low-dose and high-dose groups were slightly lower, and the model group was the lowest. Except for the low-dose and high-dose groups, the differences between the other two groups were statistically significant (P<0.05). Conclusion Spleen peptide injection can enhance the killing activity of spleen NK cells in rats with gastric cancer. Among them, 0.18 mL¡¤kg-1 spleen peptide injection has the best enhancement effect, which may be related to promoting NK cell proliferation, upregulating NK cell activating receptor NKG2D and its Ligand MICA mRNA is related to protein expression   For further details regarding this article and its research, please do not hesitate to contact our team for assistance. Original research done by Ren Hong, Zhang Jia, Zhang Zhibin, Zhang Jing, Du Ning, Qin Sida  

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